| Induction of Translocations in Spermatogonial Stem Cells |
| [2] Other animals including man |
| [Chinese hamster (Cricetulus griseus)] |
|
[Guinea-pig (Cavia porcellus)] |
|
[Marmoset (Saguinus fusciollis and Saguinas oedipus)] |
|
[Rhesus monkey (Macaca mulatta)] |
| Brewen and Preston (1974) (X-rays) |
|
Lyon and Cox (1975) (X-rays) |
|
Brewen et al. (1975) (X-rays) |
|
van Buul (1976, 1980, 1983, 1986, 1990, 1991) (X-rays) |
| Dose (Gy) |
No. of cells |
Tr (%) |
Induced (%) |
|
Dose (Gy) |
No. of cells |
Tr (%) |
Induced (%) |
|
Dose (Gy) |
No. of cells |
Tr (%) |
Induced (%) |
|
Dose (Gy) |
No. of cells |
Tr (%) |
Induced (%) |
| 0 |
|
0 |
0 |
|
0 |
1,406 |
0.1 |
0 |
|
0 |
600 |
0 |
0 |
|
0 |
6,700 |
0.04 |
0 |
| 0.5 |
|
2.7 |
2.7 |
|
1 |
1,273 |
0.7 |
0.6 |
|
0.25 |
600 |
2.8 |
2.8 |
|
0.25 |
7,290 |
0.18 |
0.14 |
| 1 |
|
7.0 |
7.0 |
|
2 |
1,504 |
1.7 |
1.6 |
|
0.5 |
600 |
3.3 |
3.3 |
|
0.5 |
13,280 |
0.29 |
0.25 |
| 2 |
|
18.6 |
18.6 |
|
3 |
1,873 |
3.0 |
2.9 |
|
1 |
600 |
7.8 |
7.8 |
|
0.75 |
1,100 |
0.45 |
0.41 |
|
|
|
|
|
4 |
1,127 |
1.2 |
1.1 |
|
2 |
200 |
7.5 |
7.5 |
|
1 |
11,650 |
0.84 |
0.80 |
| [Golden hamster (Mesocricetus auratus)] |
|
5 |
968 |
0.3 |
0.2 |
|
3 |
600 |
7.0 |
7.0 |
|
1.25 |
750 |
0.00 |
0.00 |
| Lyon and Cox (1975) (X-rays) |
|
6 |
1,268 |
0.5 |
0.4 |
|
|
|
|
|
|
1.5 |
1,050 |
0.29 |
0.25 |
| 0 |
1,013 |
0.1 |
0 |
|
|
|
|
|
|
[Marmoset (Callithrix jacchus)] |
|
1.75 |
1050 |
0.38 |
0.34 |
| 1 |
1,408 |
1.2 |
1.1 |
|
|
|
|
|
|
van Buul (1984) (X-rays) |
|
2 |
11550 |
0.56 |
0.52 |
| 2 |
1,633 |
1.7 |
1.6 |
|
[Rabbit (Oryctolagus cuniculus)] |
|
0 |
230 |
0 |
0 |
|
2.5 |
1250 |
0.56 |
0.52 |
| 3 |
1,518 |
2.0 |
1.9 |
|
Lyon and Cox (1975) (X-rays) |
|
0.5 |
260 |
0.8 |
0.8 |
|
3 |
2905 |
0.93 |
0.89 |
| 4 |
1,245 |
1.4 |
1.3 |
|
0 |
1,117 |
0.1 |
0 |
|
1 |
420 |
1.2 |
1.2 |
|
3.5 |
200 |
0.50 |
0.46 |
| 5 |
1,307 |
1.6 |
1.5 |
|
1 (×0.96) |
1,280 |
1.6 |
1.5 |
|
2 |
880 |
0.8 |
0.8 |
|
4 |
3,150 |
0 |
0 |
| 6 |
1,951 |
1.0 |
0.9 |
|
2 |
1,008 |
2.6 |
2.5 |
|
|
|
|
|
|
8 |
300 |
0 |
0 |
|
|
|
|
|
3 |
1,923 |
4.2 |
4.1 |
|
[Crab-eating monkey (Macaca fascicularis)] |
|
8.5 |
265 |
0 |
0 |
| [[Boar (Sus scrofa)] |
|
4 |
967 |
0.8 |
0.7 |
|
Matsuda et al. (1984, 1985) (γ-rays) |
|
|
|
|
|
| Erickson and Martin (1984) (γ-rays) |
|
5 |
1,248 |
0.6 |
0.5 |
|
0 |
4,700 |
0.09 |
0 |
|
[Rhesus monkey (Macaca mulatta)] |
| 0 |
300 |
0 |
0 |
|
6 |
1,055 |
0.3 |
0.2 |
|
1 |
3,500 |
1.86 |
1.77 |
|
Lyon et al. (1976) (X-rays) |
| 1 |
593 |
1.0 |
1.0 |
|
|
|
|
|
|
2 |
3,000 |
1.86 |
2.38 |
|
1 |
1,815 |
0.8 |
0.8 |
| 2 |
230 |
1.7 |
1.7 |
|
|
|
|
|
|
3 |
3,000 |
2.47 |
1.24 |
|
2 |
1,130 |
1.2 |
1.2 |
| 3 |
141 |
1.4 |
1.4 |
|
|
|
|
|
|
0.25 |
4,500 |
0.53 |
0.44 |
|
3 |
478 |
1.0 |
1.0 |
|
|
|
|
|
|
|
|
|
|
0.5 |
4,500 |
1.07 |
0.98 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
[Man (Homo sapiens)] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Brewen et al. (1975) (X-rays) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
0.78 |
371 |
4.0 |
4.0 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
2 |
300 |
4.0 |
4.0 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
6 |
180 |
6.1 |
6.1 |
References
=====
Other mammals =======
Brewen,
J. G. and Preston, R. J. (1973): Chromosomal interchanges induced by radiation
in spermatogonial cells and leukocytes of mouse and Chinese hamster. Nature New
Biol., 244:111-113.
Erichson,
B. H. and Martin, P. G. (1984): Stem-spermatogonial survival and incidence of
reciprocal translocations in the gamma-irradiated boar. Environ. Mutagen.,
6:219-227.
Lyon,
M. F. and Cox, B. D. (1975): The induction by X-rays of chromosome aberrations
in male guinea-pigs, rabbits and golden hamsters, III. Dose-response
relationship after single doses of X-rays to spermatogonia. Mutation Res.,
29:407-422.
Lyon,
M. F. and Cox, B. D. (1975): The induction by X-rays of chromosome aberrations
in male guinea pigs and golden hamsters, IV. Dose response for spermatogonia
treated with fractionated doses. Mutation Res., 30:117-127.
Oakberg,
E. F. (1975): Mammalian gametogenesis and species comparison in radiation
response of the gonads. In, “Effects of Radiation on Meiotic Systems”, Int.
Atomic Energy Agency, Vienna, pp.3-15.
Rathenberg,
R., Schwegler, H. and Miska, W. (1976): Comparative investigations on
cytogenetic effects of X-irradiation on the germinal epithelium of male mice
and Chinese hamster. Human Genet., 34:171-183.
=======
Primates =======
Brewen,
J. G. and Preston, R. J. (1978): Analysis of chromosome aberrations in
mammalian germ cells. In: Hollaender, A, and de Derres, F. J., eds., “Chemical
Mutagenesis: Principle and Methods for Their Detection”, Vol. 5, Plenum, New
York, pp.127-150.
Brewen,
J. G., Preston, R. J. and Gengozian, N. (1975): Analysis of X-ray induced
chromosomal translocations in human and marmoset spermatogonial cells. Nature,
253:468-470.
Brewen,
J. G. and Preston, R. J. (1978): Radiation induced chromosome aberration in
somatic and germ cells of the male marmoset. Primates in Medicine, 10:199-204.
Brewen,
J. G. and Preston, R. J. (1974): Cytogenetic effects of environmental mutagens
in mammalian cells and their extrapolation to man. Mutation Res., 26:297-305.
de
Rooy, D. G. (1978): The effect of X-irradiation on spermatogenesis in the
rhysus monkey. Int. J. Radiat. Biol., 34:565-566 (Abstract).
Lyon,
M. F., Cox, B. D. and Marston, J. H. (1978): Dose-response data for
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Matsuda,
Y., Tobari, I., Yamagiwa, J., Tsuji, T., Okamoto, M. and Nakai, S. (1985):
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doses in spermatogonia of the crab-eating monkey (Macaca fascicularis). Mutation Res., 151:121-127.
Matsuda,
Y., Tobari, I., Yamagiwa, J., Utsugi, T., Kitazume, M. and Nakai, S. (1984):
Mutation Res., 129:373-380.
Tobari,
I., Matsuda, Y., Xiaohung, G., Yamagiwa, J., Utsugi, T., Kitazume, M. and
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spermatogonia of the crab-eating monkey (Macaca
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van
Alphen, M. M. A., van de Kant, H. J. G., Davids, J. A. G., Warmer, C. J.,
Bootsma, A. L. and de rooij, D. G. (1989): Dose-response studies on the
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van
Buul, P. P. W., Richardson, J. F. and Goudzward, J. H. (1986): The induction of
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van
Buul, P. P. W. (1976): A comparative study of the frequencies of radiation
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van
Buul, P. P. W. (1984): X-ray induced translocations in marmoset (Callithrix jacchus) stem-cell
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van
Buul, P. P. W. (1989): The induction by ionizing radiation of chromosomal
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van
Buul, P. P. W. (1980): Dose-response relationship for X-ray induced reciprocal
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van
Buul, P. P. W. (1989): X-ray-induced reciprocal translocation in stem cell
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van
Buul, P. P. W. (1991): X-ray induced translocations in pre-meiotic germ cells
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