| Induction of Translocations in Spermatogonial Stem Cells |
| [Mouse]: Leonard and Deknudt (1969) (X-rays) |
|
Mouse: Catanach et al. (1974, 1976) (X-rays) |
|
[Mouse]: Preston and Brewen (1973) (X-rays) |
|
[Mouse]: 14.5MeV fast neutron; Valentine (1975) |
| Dose (Gy) |
No. of cells |
Tr (%) |
Induced (%) |
|
Dose (Gy) |
No. of cells |
Tr (%) |
Induced (%) |
|
Dose (Gy) |
No. of cells |
Tr (%) |
Induced (%) |
|
Dose (Gy) |
No. of cells |
Tr (%) |
Induced (%) |
| 0 |
1,900 |
0.053 |
0 |
|
8 |
1,700 |
10.0 |
10.0 |
|
0 |
600 |
0 |
0 |
|
0 |
4,700 |
0 |
0 |
| 2.5 |
1,600 |
4.75 |
4.70 |
|
10 |
650 |
5.0 |
5.0 |
|
0.5 |
600 |
0.7 |
0.7 |
|
0.75 |
1,900 |
0.7 |
0.7 |
| 5 |
1,700 |
8.12 |
8.07 |
|
|
|
|
|
|
1 |
600 |
1.5 |
1.5 |
|
1.5 |
1,900 |
0.8 |
0.8 |
| 7.5 |
1,925 |
5.46 |
5.41 |
|
[Mouse]: Catanach and Kirk (1978) (X-rays) |
|
1.5 |
600 |
2.5 |
2.5 |
|
2.5 |
2,500 |
1.6 |
1.6 |
| 10 |
1,600 |
1.56 |
1.51 |
|
0.5 |
550 |
0.9 |
0.9 |
|
2 |
600 |
4.3 |
4.3 |
|
2.5(chronic) |
2,700 |
2.2 |
2.2 |
| 12.5 |
1,275 |
1.96 |
1.91 |
|
1 |
483 |
0.8 |
0.8 |
|
3 |
600 |
7.3 |
7.3 |
|
|
|
|
|
|
|
|
|
|
1.5 |
450 |
2.2 |
2.2 |
|
4 |
800 |
13.5 |
13.5 |
|
[Mouse]: BEPO fast neutron; Searle et al. (1969) |
| [Mouse]: Leonard and Deknudt (1967) (X-rays) |
|
2 |
650 |
6.9 |
6.9 |
|
5 |
800 |
17.0 |
17.0 |
|
Dose (Gy) |
No. of cells |
Tr (%) |
Induced (%) |
| 1 |
1,500 |
3.87 |
3.82 |
|
3 |
900 |
6.3 |
6.3 |
|
6 |
800 |
19.5 |
19.5 |
|
0 |
600 |
0 |
0 |
| 2 |
1,800 |
4.39 |
4.34 |
|
4 |
800 |
7.0 |
7.0 |
|
7 |
800 |
13.5 |
13.5 |
|
0.25 |
1,600 |
2.3 |
2.3 |
| 3 |
1,350 |
6.15 |
6.10 |
|
5 |
1,050 |
7.3 |
7.3 |
|
8 |
600 |
10.2 |
10.2 |
|
0.5 |
1,600 |
5.6 |
5.6 |
| 4 |
1,750 |
6.48 |
6.43 |
|
6 |
1,250 |
6.7 |
6.7 |
|
12 |
600 |
4.5 |
4.5 |
|
1 |
1,600 |
8.7 |
8.7 |
| 5 |
1,300 |
8.31 |
8.26 |
|
6 |
1,250 |
9.6 |
9.6 |
|
|
|
|
|
|
1.4 |
2,200 |
4.7 |
4.7 |
| 6 |
640 |
10.78 |
10.73 |
|
7 |
554 |
6.0 |
6.0 |
|
[Mouse]: Preston and Brewen (1976) (X-rays) |
|
1.88 |
2,609 |
3.5 |
3.5 |
|
|
|
|
|
8 |
600 |
5.0 |
5.0 |
|
0 |
1,000 |
0 |
0 |
|
2.2 |
1,800 |
1.6 |
1.6 |
| [Mouse]: Leonard and Deknudt (1968) (X-rays) |
|
|
|
|
|
|
2.5 |
500 |
6.0 |
6.0 |
|
|
|
|
|
| 0.25 |
2,400 |
0.42 |
0.38 |
|
[Mouse]: Catanach and Crocker (1979) (X-rays) |
|
5 |
506 |
17.0 |
17.0 |
|
[Mouse]: Fission neutrons; Searle et al. (1969) |
| 0.5 |
2,400 |
0.67 |
0.62 |
|
6 |
500 |
11.0 |
11.0 |
|
5 |
800 |
17.0 |
17.0 |
|
GLEEP fission neutron, 0.7MeV, Á=18.9% |
| 0.75 |
2,400 |
1.58 |
1.53 |
|
6 |
700 |
10.0 |
10.0 |
|
10 |
500 |
5.0 |
5.0 |
|
Dose (Gy) |
No. of cells |
Tr (%) |
Induced (%) |
| 1 |
2,400 |
2.13 |
2.08 |
|
7 |
700 |
7.0 |
7.0 |
|
4 |
2,150 |
14.0 |
14.0 |
|
0.01 |
200 |
0 |
0 |
|
|
|
|
|
8 |
800 |
7.0 |
7.0 |
|
8 |
1,202 |
20.0 |
20.0 |
|
0.025 |
400 |
0.5 |
0.5 |
| [Mouse]: Searle et al. (1968) (X-rays) |
|
10 |
650 |
5.0 |
5.0 |
|
|
|
|
|
|
0.05 |
800 |
0.42 |
0.42 |
| 6 |
1600 |
12.81 |
12.81 |
|
|
|
|
|
|
[Mouse]: Muramatsu et al. (1971) (X-rays) |
|
0.1 |
80 |
0.63 |
0.63 |
| 6 |
1600 |
12.08 |
12.08 |
|
[Mouse]: van Buul et al (1973, 1974, 1977) |
|
0 |
2,000 |
0 |
0 |
|
0.2 |
700 |
1.57 |
1.57 |
|
|
|
|
|
0 |
2,000 |
0 |
0 |
|
0.5 |
1,000 |
1.2 |
1.2 |
|
0.4 |
700 |
2.14 |
2.14 |
| [Mouse]: Searle et al. (1971) (Á-rays) |
|
4 (Á) |
1,400 |
6.7 |
6.7 |
|
1 |
1,000 |
3.7 |
3.7 |
|
0.6 |
700 |
2.86 |
2.86 |
| 0.225 |
200 |
0 |
0 |
|
4 (X) |
1,300 |
7.5 |
7.5 |
|
2 |
2,000 |
7.2 |
7.2 |
|
0.8 |
1,000 |
3.10 |
3.10 |
| 0.45 |
1,000 |
0.40 |
0.40 |
|
4 (X) |
1,000 |
4.7 |
4.7 |
|
3 |
1,600 |
8.4 |
8.4 |
|
1 |
1,000 |
3.50 |
3.50 |
| 0.9 |
620 |
1.29 |
1.29 |
|
6 (X) |
2,600 |
7.3 |
7.3 |
|
4 |
1,400 |
8.9 |
8.9 |
|
1.2 |
740 |
1.89 |
1.89 |
| 1.45 |
400 |
2.25 |
2.25 |
|
|
|
|
|
|
5 |
1,000 |
10.3 |
10.3 |
|
1.6 |
600 |
1.83 |
1.83 |
| 2.03 |
600 |
3.17 |
3.17 |
|
[Mouse]: van Buul and Leonard (1980) (X-rays) |
|
6 |
1,000 |
13.5 |
13.5 |
|
2 |
550 |
1.09 |
1.09 |
| 3 |
450 |
4.89 |
4.89 |
|
0 |
2,000 |
0 |
0 |
|
7 |
800 |
14.1 |
14.1 |
|
|
|
|
|
| 4.17 |
600 |
6.20 |
6.20 |
|
0.25 |
2,000 |
0.4 |
0.4 |
|
|
|
|
|
|
[Mouse]: Fission neutrons; Grahn et al. (1984) |
| 5.69 |
600 |
8.80 |
8.80 |
|
0.5 |
2,500 |
0.8 |
0.8 |
|
[Mouse]: "scid" mouse |
|
JANUS fission neutrons, E(av)=0.85MeV, Á=4% |
|
|
|
|
|
0.75 |
1,900 |
0.9 |
0.9 |
|
van Buul et al. (1995, 1996) (X-ray) |
|
Dose (Gy) |
No. of cells |
Tr (%) |
Induced (%) |
| [Mouse]: Lyon and Morris (1969) (X-rays) |
|
1 |
2,000 |
1.3 |
1.3 |
|
Dose (Gy) |
No. of cells |
Tr (%) |
Induced (%) |
|
0 |
6,044 |
0.033 |
0.0 |
| 0 |
2,000 |
0 |
0 |
|
10 |
1,700 |
2.5 |
2.5 |
|
0.001 |
1,400 |
0.071 |
0.071 |
|
0.01 |
3,160 |
0.063 |
0.030 |
| 10 |
2,000 |
5.3 |
5.3 |
|
|
|
|
|
|
0.025 |
1,600 |
0.063 |
0.063 |
|
0.025 |
3,600 |
0.250 |
0.217 |
|
|
|
|
|
[Mouse]: Evans et al. (1970) (X-rays) |
|
0.05 |
1,400 |
0.429 |
0.429 |
|
0.05 |
1,810 |
0.330 |
0.290 |
| [Mouse]: Lyon et al. (1970) (X-rays) |
|
0.5 |
1,000 |
1.4 |
1.4 |
|
0.075 |
1,600 |
0.313 |
0.313 |
|
0.1 |
1,900 |
1.000 |
0.968 |
| 3 |
1,620 |
6.3 |
6.3 |
|
1 |
1,200 |
2.6 |
2.6 |
|
0.1 |
1,400 |
0.429 |
0.429 |
|
0.2 |
1085 |
0.740 |
0.707 |
|
|
|
|
|
2 |
1,200 |
8.0 |
8.0 |
|
0.15 |
1,400 |
0.429 |
0.429 |
|
0.4 |
1,200 |
2.080 |
2.047 |
| Mouse: Catanach et al. (1977) (X-rays) |
|
4 |
1,200 |
11.8 |
11.8 |
|
0.2 |
1,600 |
0.25 |
0.25 |
|
|
|
|
|
| 3 |
950 |
5.75 |
5.75 |
|
8 |
1,200 |
16.5 |
16.5 |
|
0.3 |
1,600 |
0.188 |
0.188 |
|
|
|
|
|
| 5 |
1000 |
10.10 |
10.10 |
|
3 |
1,200 |
7.9 |
7.9 |
|
0.4 |
1,800 |
0.167 |
0.167 |
|
|
|
|
|
| 10 |
650 |
4.15 |
4.15 |
|
3 |
1,200 |
7.3 |
7.3 |
|
0.5 |
1,600 |
0.125 |
0.125 |
|
|
|
|
|
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