A-bomb survivors: Bone marrow studies (Kamada et al. 1970; Kamada and Tanaka 1983)

Scenario

N. Kamada and others in Hiroshima University studied chromosome aberrations in bone marrow of 115 cases of A-bomb survivors. Chromosomal abnormalities were observed in BM cells of proximally exposed, but healthy, survivors. Some of these abnormalities appeared as clones, in which Ph¹-like abnormality was the most common abnormality. In some survivors, the similar abnormality was also found in the peripheral blood T-lymphocytes.

References

Kamada, N., Tsuchimoto, T. and Uchino, H. (1970): Smaller G chromosomes in the bone-marrow cells of healthy irradiated atomic-bomb survivors. Lancet, ii:880-881.
Kamada, N. and Tanaka, K. (1983): Cytogenetic studies of hematological disorders in atomic bomb survivors. In, Ishihara, T. and Sasaki, M. S., eds. “Radiation-induced Chromosome Damage in Man”, Alan R. Liss, Inc., New York, pp.455-474.

Observations

.
	Gound distance	No. of	No. of	Chromosome aberrations observed in
	(km)	subjects	BM cells	No. of cells (%)	Subjects (%)	Clone*
	0-0.5	28	1,269	279 (22.0)	26 (92.8)	7
	0.5-1.0	23	1,078	116 (11.3)	15 (65.2)	7
	1.0-1.5	18	556	1 (0.2)	1 (6.2)	0
	1.5-2.0	23	728	0	0	0
	2.0-3.0	23	737	1 (0.4)	1 (4.3)	0
	Controls	17	624	0	0	0
	*) Most common aberrations found in clones are Ph¹-like aberrations, i.e., 22q-.
							.

Distribution of breakpoints involved in the formation of chromosome aberrations in T-lymphocytes. Hot spots on chromosome 22q suggest the common susceptibility to breakage between lymphocytes and bone marrow cells