192Ir Accident, Samara, Russia (15 August, 2000)

Reference
      Sevanfkaev, A. V., Lloyd, D. C., Edwards, A. A., Moquet, J. E., Nugis, V. Yu., Mikhailova, G. M., Potetnya, O. J., Khvostunov, I. K., Guscova, A. K., Baranov, A. E. and Nadejina, N. M. (2002): Cytogenetic investigations of serious overexposures to an industrial gamma radiography souce. Radiat. Protect. Dosimet., 102:201-206.


Accident scenario
      The accident occurred on 15 August 2000 in Samara district of Russia (day 1). Three subjects, S1, S2 and S3, employees of the gas pipeline service and repair company (S1 and S2 were industrial radiographers, S3 was their lorry driver) were seriously overexposed to gamma-rays from a 9 TBq iridium-192 source that had detached from its wind-out cable so that it had not retracted into its shielded container. It is uncertain whether the source was in a wooden box (B) or in a steel box (A). They were unaware of this, moved about around inside and outside of the lorry for next 5-6 h, and slept for 4 h on bunks inside the lorry. They suffered nausea and vomiting in the morning. The lorry was parked and not used for several days except for two 3 h drive to their base and back until they discover that the source was loose in the guide tube (day 9). On day 30 they were all diagnosed to exhibit acute radiation sickness.

Physical dose and early clinical findings
Age Calculated dose (Gy) Haemoglobin Erythrocytes Reticulocytes Thrombocytes Leukocytes Neutrophyls Lymphocytes Monocytes Erythrocyte sedimentation rate
(yrs) Head Torso Legs (g/l) (~1012/l) (%) (~109/l) (~109/l) (~109/l) (%) (%) (mm/h)
S1 33 2.33 4.10 44.89 135 4.2 1.0 126 2.2 0.43 59 10 18
S2 65 2.88 1.84 2.21 143 4.7 1.0 117 3.4 0.75 39 7 30
S3 26 3.84 3.03 2.29 110 3.3 1.0 39 0.25 0.02 too few too few 50
 

Chromosome aberration analysis

Subject Sampled No of Aberrations* Distribution of dicentrics
on day: cells AC cR Dic 0 1 2 3 4 5 6
S1 30 880 112 24 249 660 192 27 1
36 1,074 82 10 164 935 116 21 2
391 1,697 88 59 247 1,487 178 28 3 1
S2 30 279 39 4 77 211 60 7 1
36 1,119 127 20 178 959 18
S3 30 348 72 11 176 222 91 24 8 2 1
36 1,354 169 43 311 1,099 201 40 6 1
157 620 77 18 158 501 87 26 5 1
*) AC: acentric fragments, acentric rings, minutes. cR: centric rings. Dic: dicentrics .


Supplementary information by M. S. Sasaki: Assessment of equivalent whole-bady dose (EWBD) and dose distribution profile by unfolding dicentric distribution