Lymphocyte chromosome aberrations in Thorotrast patients (part 1 of 3)

     Thorotrast is a colloidal suspension of radioactive thorium dioxide (232ThO2), first introduced as a new X-ray contrast medium (e.g., hepatolienography) in 1982 (Oka, M; Bluhbaum, T.), soon after it was commercialized as an X-ray contrast medium for angiography, and thence widely used throughout Europe, Japan and North America during the World War II until the warning for adverse health effects, such as hepatic cancers add leukemia. In Japan a total of 20-33 thousands persons have been estimated to have had injection, mostly in the military and navy hospitals and approximately 5000 of them were assumed to have survived as of 1973 (Mori, T., Emviron. Res., 18:44-54, 1979). Among those, 255 persons could be followed up. Chromosomes were studied in peripheral blood lymphocytes in 77 patients.

Refs:
     Sasaki, M. S., Miyata, H., Mori, T. and Kido, C. (1977). Chromosome aberrations in Thorotrat paients. HOSHASENKAGAKU, 20:111-112, in Japanese.
     Sasaki, M. S., Takatsuji, T., Ejima, Y., Kodama, S. and Kido, C. (1987). Chromosome aberration frequency and radiation dose to lymphocytes by alpha-particles from internal deposit of Thorotast. Radiat. Environ. Biophys., 26:227-238.
     Sasaki, M. S. (1992). Cytogenetic biomonitoring of human radiation exposure: possibility, problems and pitfalls. J. Radiat. Res., 33(suppl):44-53.

  

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Patient Date of Age Sex No. of Aberrations Distribution of cells with indicated number of aberrations
ID sampling (yrs) cells Cu Cs Tet Tri Dic Rc Ra aM F del S del Aberr 0 1 2 3 4 5 6 7 8 9 10
TR001AbHa 1967.07.26 72 F 400 48 9 0 2 45 8 7 21 73 25 14 11 Dics 364 27 5 4
Myelodysplastic syndrome (MDS) D+R 362 19 13 5 1
Del 373 19 7 1
All 343 28 6 16 4 1 2
TR002TuSa 1968.10.17 73 F 800 125 26 0 5 113 20 10 51 135 29 93 58 Dics 713 62 17 5 3
D+R 697 72 18 7 6
Del 740 39 16 4 1
All 649 83 31 16 13 4 2 2
TR003TaSy 1969.03.03 51 M 500 64 10 0 3 47 15 7 29 64 10 39 26 Dics 457 34 8 1
D+R 448 34 13 5
Del 473 22 2 2 1
All 426 40 19 6 5 1 2 1
TR004SuSa 1974.06.06 77 F 600 69 7 0 1 77 14 3 18 91 13 27 17 Dics 549 30 17 3 1
D+R 539 37 18 4 1 1
Del 578 17 4 1
All 524 35 25 11 3 1 1
TR005KuSy 1975.04.22 68 M 700 119 25 0 8 142 34 14 51 195 13 36 29 Dics 609 52 21 12 4 1 1
Myelodysplastic syndrome (MDS) D+R 590 59 25 13 10 1 1 1
Del 667 28 3 1 1
All 556 72 35 13 12 8 2 1 1
TR006OkCh 1975.10.14 64 F 500 52 8 1 6 45 9 2 17 75 11 15 11 Dics 463 22 10 3 1 1
D+R 459 25 9 3 2 1 1
Del 481 16 3
All 400 34 12 9 2 1 2
TR007TaTa 1976.02.05 57 F 557 94 18 0 4 92 11 5 33 119 14 40 36 Dics 493 40 15 6 3
D+R 484 44 20 5 3 1
Del 516 34 6 1
All 445 65 24 15 4 1 1 2
TR008NaTo 1976.02.05 62 M 500 96 15 2 9 118 13 7 47 172 28 40 33 Dics 423 42 19 7 5 3 1
D+R 417 41 22 9 6 4 1
Del 455 34 8 1 2
All 389 47 24 16 9 5 7 2 1
TR009MaYo 1976.02.05 58 M 500 43 15 0 1 50 5 4 20 55 3 12 9 Dics 464 23 10 3
D+R 461 22 13 3 1
Del 490 8 2
All 442 36 12 7 3
TR010OhKa 1976.02.25 62 M 1200 104 15 1 7 102 14 9 35 136 15 44 33 Dics 1124 49 16 7 3 1
D+R 1114 52 19 9 5 1
Del 1159 36 4 1
All 1081 67 26 10 8 6 1 1
TR011HaKa 1976.11.12 50 F 728 15 4 0 1 13 5 2 8 21 3 7 6 Dics 718 7 2 1
D+R 716 5 6 1
Del 422 4 1 1
All 709 10 3 5 1
TR012OdMa 1976.12.22 60 M 628 34 10 2 0 41 6 3 18 56 6 9 8 Dics 599 14 12 3
D+R 598 13 9 7 1
Del 617 9 1 1
All 584 18 16 6 1 2 1
TR013YaYo 1976.12.22 59 M 722 33 7 0 3 19 11 7 12 38 8 11 6 Dics 705 10 6 1
D+R 695 15 8 4
Del 710 10 2
All 682 22 9 7 2
TR014AsSe 1976.12.22 59 M 728 26 5 0 2 22 9 6 11 37 3 6 6 Dics 710 11 6 1
D+R 706 10 6 5 1
Del 720 7 1
All 697 14 8 5 4
TR015MiIw 1977.04.08 61 M 727 19 6 0 2 20 6 2 12 31 4 7 5 Dics 713 7 5 1 1
D+R 711 7 5 2 1 1
Del 720 6 1
All 702 12 7 2 1 2 1
TR016TaNo 1977.05.09 62 M 300 30 6 0 3 31 6 8 9 45 2 6 5 Dics 276 14 7 3
D+R 274 11 9 5 1
Del 293 7
All 264 19 9 5 3
TR017MaNo 1977.06.03 71 M 500 61 12 0 7 61 13 3 30 86 8 19 10 Dics 452 30 12 3 3
D+R 445 32 13 6 3 1
Del 484 14 2
All 427 38 17 9 5 2 2
TR018TaHi 1977.08.23 59 M 300 6 1 0 0 4 2 1 1 7 1 0 0 Dics 296 4
D+R 295 3 2
Del 299 1
All 293 5 2
TR019OiSa 1977.08.22 64 M 483 48 4 1 2 43 12 9 15 74 25 6 4 Dics 452 17 10 3 1
D+R 443 20 12 5 3
Del 465 11 5 2
All 431 16 20 9 5 2
TR020KaSu 1978.04.12 75 M 500 21 2 0 0 15 3 2 3 22 9 2 2 Dics 486 13 1
D+R 483 14 3
Del 490 9 1
All 477 15 5 3
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