Thorotrast patients: Biodosimetry

Thorotrast patients: Summary of the table

Frequencyis of dicentrics (per cell)			No. of	No. of	Aberrations												Distribution of cells with indicated number of dicentrics
Group	Range	Mean	subjects	cells	Cu	Cs	Tet	Tri	Dic	Rc	Ra	aM	F	del	S	del	Aberr	0	1	2	3	4	5	6	7
I	0≤μ<0.025	0.0098	21	5,103	85	31	0	1	48	16	11	41	81	25	29	26	Dics	5,062	35	4	1	1	-	-	-
II	0.025≤μ<0.05	0.0345	23	6,979	273	86	0	10	221	54	34	132	314	57	77	61	Dics	6,802	127	38	10	2	-	-	-
III	0.05≤μ<0.1	0.0800	13	4,311	316	62	3	12	326	51	25	127	401	52	140	90	Dics	4,084	144	54	27	4	1	-	-
IV	0.1≤μ<0.2	0.1289	15	6,286	749	140	2	38	728	147	65	278	983	151	302	210	Dics	5,742	355	131	43	12	2	1	-
V	0.2≤μ	0.2657	5	1,750	358	58	2	22	415	65	33	147	558	60	120	98	Dics	1,465	178	64	25	10	5	2	1

Dose to lymphocyte nucleus by traversal of 5 MeV alpha particles (track average LET of 132.24 keV/micrometer in ICRU muscle equivalent material)

Biological dosimetry: Assessment of dose distribution profile by unfolding distribution of dicentrics (Method: Sasaki, M. S., Int. J. Radiat. Biol., 79:83-97, 2003)
(The dose profiles were those adjusted by lymphocyte survival, Do=3Gy, after Edwards et al., Int. J. Radiat. Biol., 38:83-91, 1980.)