Residents Near the Semipalatinsk Nuclear Test Site (Kazakhstan) |
Chromosome aberration and mutation analysis
Date of blood sampling: May 16-19, 2000.
Whole blood was immediately mixed with cold stimulation medium and brought by plane to the RBC-Kyoto University, where lymphocyte cultures
were established on May 26, 2000.
Blood was kept in the cool during travelling including transit stay in
Moscow.
 |
. |
Village |
ID |
Age |
Sex |
Aberrations |
Mutations**) |
|
|
No. of |
Dics + |
mN |
NO |
NN |
TCR |
|
|
(yrs) |
cells |
Rings |
type |
(10-4) |
(10-6) |
(10-4) |
|
|
Kurchatov |
K01 |
80 |
M |
500 |
1 |
mN |
39 |
14 |
1.7 |
|
|
|
K02 |
49 |
F |
400 |
0 |
mm |
- |
- |
0.7 |
|
|
|
K03*) |
47 |
M |
492 |
3 |
mm |
- |
- |
1.1 |
|
|
|
K04*) |
58 |
M |
530 |
0 |
NN |
- |
- |
1.5 |
|
|
|
K05 |
56 |
M |
495 |
6 |
mm |
- |
- |
1.3 |
|
|
|
K06 |
42 |
M |
420 |
1 |
mN |
62 |
10 |
2.9 |
|
|
|
K07*) |
56 |
F |
529 |
1 |
mm |
- |
- |
1.4 |
|
|
|
K08*) |
44 |
F |
650 |
2 |
mN |
20 |
6 |
0.8 |
|
|
|
K09 |
48 |
F |
605 |
2 |
mm |
- |
- |
1.1 |
|
|
|
K10 |
49 |
M |
405 |
0 |
mm |
- |
- |
2.3 |
|
|
Akzhar |
A01 |
59 |
F |
660 |
1 |
mm |
- |
- |
2.3 |
|
|
|
A02 |
58 |
F |
362 |
0 |
mm |
- |
- |
1.1 |
|
|
|
A03 |
34 |
M |
642 |
1 |
NN |
- |
- |
1.9 |
|
|
|
A04 |
48 |
F |
403 |
0 |
mN |
12 |
8 |
2.0 |
|
|
|
A05 |
58 |
F |
506 |
0 |
mN |
11 |
6 |
1.3 |
|
|
|
A06 |
55 |
M |
650 |
1 |
mN |
15 |
10 |
3.4 |
|
|
|
A07 |
59 |
F |
500 |
0 |
NN |
- |
- |
0.9 |
|
|
|
A08 |
49 |
M |
300 |
0 |
mN |
25 |
14 |
1.6 |
|
|
|
A09 |
36 |
M |
326 |
0 |
mN |
13 |
12 |
9.5 |
|
|
|
A10 |
40 |
M |
631 |
1 |
mm |
- |
- |
1.4 |
|
|
Sarzhal |
A01 |
60 |
M |
490 |
4 |
mN |
15 |
5 |
12.7 |
|
|
|
S02 |
50 |
M |
360 |
0 |
mm |
- |
- |
ND |
|
|
|
S03 |
69 |
M |
500 |
1 |
mm |
- |
- |
1.4 |
|
|
|
S04 |
47 |
F |
500 |
0 |
mN |
6 |
10 |
ND |
|
|
|
S05 |
57 |
F |
500 |
1 |
NN |
- |
- |
0.8 |
|
|
|
S06 |
68 |
M |
400 |
0 |
mm |
- |
- |
ND |
|
|
|
S07 |
39 |
F |
382 |
0 |
mN |
15 |
7 |
1.8 |
|
|
|
S08 |
50 |
F |
500 |
0 |
mm |
- |
- |
4.2 |
|
|
|
S09 |
43 |
F |
510 |
1 |
mm |
- |
- |
2.8 |
|
|
|
S10 |
55 |
F |
508 |
0 |
mm |
- |
- |
0.7 |
|
|
*) Worked in the nuclear test sites. |
|
|
|
|
|
|
**) GPA and TCR mutations were studued by S. Kyoizumi and T. Seyama (RERF). |
. |
|
Semipalatinsk nuclear test site: Dates of nuclear test and flow of the
associated cloud and presumed dose (Gy).
|
Distribution of persons with indicated
frequencies of dic+ring aberrations. Control Japanese populations were
not matched for age, sex and smoking habit. Among three outlyers in the
exposed populations, two (0.616 dic+ring/100 cells and 1.212 dic+ring/100
cells) are residents in Kurchatov, another (0.816 dic+ring/100 cells) is
a member of Sarzhal. |