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23 MeV Alpha-particles |
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Cyclotron-produced alpha-particles (with or without magnetic field) |
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Kyoto University Cyclotron Laboratory |
□ Irradiation system |
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Materials: Human peripheral blood lymphocytes |
□ Sample preparation |
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(1) No magnetic field |
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Dose* |
No. of |
Dics |
Distribution of cells with indicated number of dicentrics |
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(Gy) |
cells |
0 |
1 |
2 |
3 |
4 |
5 |
6 |
7 |
8 |
9 |
10 |
11 |
≧12 |
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0.26 |
800 |
148 |
675 |
107 |
14 |
3 |
1 |
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0.50 |
500 |
197 |
351 |
111 |
29 |
8 |
1 |
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1.00 |
500 |
364 |
271 |
134 |
67 |
19 |
7 |
1 |
1 |
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1.50 |
500 |
608 |
179 |
158 |
90 |
42 |
17 |
10 |
2 |
2 |
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2.00 |
324 |
560 |
74 |
93 |
75 |
47 |
15 |
10 |
5 |
4 |
1 |
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2.56 |
400 |
726 |
117 |
84 |
70 |
63 |
40 |
14 |
5 |
4 |
2 |
1 |
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2.99 |
94 |
293 |
9 |
13 |
19 |
15 |
11 |
16 |
7 |
2 |
1 |
1 |
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(2) Magnetic field (1 Tesla) |
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Dose* |
No. of |
Dics |
Distribution of cells with indicated number of dicentrics |
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(Gy) |
cells |
0 |
1 |
2 |
3 |
4 |
5 |
6 |
7 |
8 |
9 |
10 |
11 |
≧12 |
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0.26 |
200 |
56 |
153 |
39 |
7 |
1 |
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0.50 |
250 |
134 |
155 |
68 |
16 |
10 |
1 |
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1.00 |
200 |
183 |
92 |
65 |
22 |
14 |
4 |
2 |
1 |
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1.50 |
200 |
279 |
61 |
58 |
44 |
24 |
6 |
6 |
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1 |
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2.00 |
200 |
348 |
53 |
47 |
43 |
31 |
15 |
7 |
2 |
1 |
1 |
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2.56 |
200 |
387 |
44 |
54 |
33 |
34 |
20 |
9 |
3 |
2 |
1 |
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2.99 |
150 |
405 |
17 |
27 |
39 |
25 |
18 |
6 |
10 |
4 |
3 |
3 |
1 |
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*) The dose has been calculated based on the stopping power of water, in which oxygen is |
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the major target for alpha-particle. The dose could be 62.94% higher for the ICRU muscle. |
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Refs: |
Takatsuji, T. and Sasaki, M. S. (1984), Int. J. Radiat. Biol., 45:237-243. |
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Sasaki, M.S., Takatsuji, T. and Ejima, Y. (1998), Radiat. Res., 150:253-258. |
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Takatsuji, T., Sasaki, M. and Takekoshi, H. (1989), J. Radiat. Res., 30:238-246. |
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Takatsuji, T, Yoshikawa, I. and Sasaki, M. S. (1999), J. Radiat. Res., 40:59-69. |
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